![]() These elaborations on the conserved NMD mechanism permit more sensitive post-transcriptional gene regulation but can have severe deleterious consequences, including the failure to degrade pathogenic aberrant mRNAs in many B cell lymphomas. NMD has adapted to this challenge by employing mechanisms to enhance identification of certain potential substrates, while using sequence-specific RNA-binding proteins to shield others from detection. In vertebrates, increased transcriptome complexity requires balance between these two functions since high NMD efficiency is desirable for maintenance of quality control fidelity but may impair expression of normal mRNAs. The ability of the NMD pathway to recognize mRNP features of diverse potential substrates allows it to simultaneously perform quality control and regulatory functions. ![]() A picture of NMD is emerging in which many factors contribute to the dynamics of decay complex assembly and disassembly, thereby influencing the probability of decay. The core NMD machinery, centered on the RNA helicase UPF1, integrates this information to determine the efficiency of decay. Together, these interactions allow the pathway to collect copious information about the translating mRNA, including translation termination status, splice junction positions, mRNP composition, and 3′UTR length and structure. Method for electrochemically detecting nucleic acid-oligomer hybridisation events.The nonsense-mediated mRNA decay pathway selects and degrades its targets using a dense network of RNA-protein and protein–protein interactions. With CYCLE Dx and Lab-direct we have developed two. Our vision is to make fastest quality diagnostics accessible to anyone, to allow for right treatment at the right time and to provide near patient diagnostics that can be used with as little laboratory equipment and training as possible. Taking Point-of-Care testing to the next level. The CYCLE® Dx platform is comprised of a compact processing unit and two sophisticated disposable components. FRIZ Biochem GmbH 107 obserwujcych na LinkedIn. New apparatus, useful for detecting biomolecules and polymers, comprises array of samples containing specific molecules with separate light sources and system for detecting which samples interact with molecule to be detected Anytime Anywhere CYCLE® Dx Our unique diagnostic solution provides for multi-parametric, rapid, sensitive and fully automated molecular testing truly at the P oint-of-Care. Process for the preparation of quinone derivatives and their useĪ new electrochemical nucleic acid probe comprises an oligonucleotide bound to a thermostable photosynthetic reaction center is useful to detect hybridized nucleic acids 6 Munich Germany 49 89 72 44 09 14 Nanotechnology Company Directory. 20224 Jahre 7 Monate Interfaculty Institute for. Molecular electronic component for building nanoelectronic circuits, molecular electronic assembly, electronic circuit and manufacturing processįluorescence quenching for the detection of ligate-ligand association events in electric fieldsĭisplacement assay for the detection of ligate-ligand association events 2022Heute2 Monate Neuried, Bavaria, Germany University of Tbingen 6 Jahre Doctoral Researcher Okt. Multifunctional reagent for the synthesis of thiol modified oligomersĭark-field imaging device for spatially resolved dark-field imaging of a flat sampleįluorescence quenching for the detection of nucleic acid oligomer hybridization events at high salt concentrations and Young, revealing an underlying unity in biochemistry. Meyerhof was born in Hanover, Germany and grew up in Berlin. Method for the qualitative and quantitative comparative detection of chemical substances combined efforts of several scientists including Otto Fritz Meyerhof (18841951). for diagnostic tests, comprises using solid support that includes one or more built-in reference regions to indicate complete (optionally also zero or partial) hybridization for diagnosis and toxicological testing, includes measuring chamber where ligands and sample are applied to a biochip that carries binding agentsĭetection of oligonucleotide hybridization comprises electrochemically detecting reduction and/or oxidation of a redox-active speciesĭetecting nucleic acid-oligonucleotide hybridization, useful e.g. Method and device for wetting a substrate with a liquidĮlectrochemical device for detecting ligand-binding reactions, useful e.g. Substrate for controlled wetting of predetermined wetting points with small liquid volumes, substrate cover and flow chamber ![]() Substrate for controlled binding reactions, useful for (high throughput) nucleic acid hybridization assays, comprises carrier having a depression in which there are many test sites, separated by embankments FRIZ Biochem GmbH 107 (na) tagasubaybay sa LinkedIn.
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